Formaldehyde formation in the glycine cleavage system and its use for an aldolase-based biosynthesis of 1,3-prodanediol
Abstract Glycine cleavage system (GCS) occupies a key position in one-carbon (C1) metabolic pathway and receives great attention for the use of C1 carbons like formate and CO2 via synthetic biology.In this work, we demonstrate that formaldehyde exists as a substantial byproduct of the GCS reaction cycle.Three causes are Socks identified for its for